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pentobarbital will lessen the extent or influence of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.In retrospect, many of the fears and hopes that coalesced around the NuTech move